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A Novel Autoantibody Induced by Bacterial Biofilm Conserved Components Aggravates Lupus Nephritis.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Mar 25; Vol. 12, pp. 656090. Date of Electronic Publication: 2021 Mar 25 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple autoantibody production and often affects the kidneys, known as lupus nephritis. However, the mechanism underlying lupus nephritis development is unclear. Biofilms that protect bacteria from stress are ubiquitous in almost every environment. Here, we identified that a conserved peptide (HU1) derived from DNABII proteins, one of major bacterial biofilm components, was specifically recognized by sera from about 47% patients with SLE. Moreover, the serum anti-HU1 levels showed a significant positive correlation with lupus nephritis occurrence. Presence of antibodies against HU1 in pristane-induced mice aggravated lupus nephritis, although these antibodies also attenuated bacterial biofilm formation. We further identified that antibodies against HU1 cross-recognized protein disulfide isomerase (P4HB) located on the renal cell surface and inhibited the activities of this enzyme. Our findings reveal a novel mechanism underlying the development of lupus nephritis triggered by bacterial biofilms.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Fu, Liu, Liu, Liu, Li, Niu, Han, Xu, Hou, Ma, Feng, Li, Mu and Yang.)
- Subjects :
- Amino Acid Sequence
Animals
Antigens, Bacterial chemistry
Antigens, Bacterial immunology
Autoantibodies blood
Autoantigens immunology
Biomarkers
Disease Models, Animal
Disease Progression
Disease Susceptibility
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Lupus Erythematosus, Systemic pathology
Lupus Nephritis blood
Mice
Mice, Transgenic
Peptides chemistry
Peptides immunology
Terpenes adverse effects
Autoantibodies immunology
Bacteria immunology
Biofilms
Lupus Erythematosus, Systemic complications
Lupus Erythematosus, Systemic immunology
Lupus Nephritis etiology
Lupus Nephritis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33841441
- Full Text :
- https://doi.org/10.3389/fimmu.2021.656090