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The role of APOE in cognitive trajectories and motor decline in Parkinson's disease.
- Source :
-
Scientific reports [Sci Rep] 2021 Apr 09; Vol. 11 (1), pp. 7819. Date of Electronic Publication: 2021 Apr 09. - Publication Year :
- 2021
-
Abstract
- We aimed to investigate the role of the APOE genotype in cognitive and motor trajectories in Parkinson's disease (PD). Using PD registry data, we retrospectively investigated a total of 253 patients with PD who underwent the Mini-Mental State Exam (MMSE) two or more times at least 5 years apart, were aged over 40 years, and free of dementia at the time of enrollment. We performed group-based trajectory modeling to identify patterns of cognitive change using the MMSE. Kaplan-Meier survival analysis was used to investigate the role of the APOE genotype in cognitive and motor progression. Trajectory analysis divided patients into four groups: early fast decline, fast decline, gradual decline, and stable groups with annual MMSE scores decline of - 2.8, - 1.8, - 0.6, and - 0.1 points per year, respectively. The frequency of APOE ε4 was higher in patients in the early fast decline and fast decline groups (50.0%) than those in the stable group (20.1%) (p = 0.007). APOE ε4, in addition to older age at onset, depressive mood, and higher H&Y stage, was associated with the cognitive decline rate, but no APOE genotype was associated with motor progression. APOE genotype could be used to predict the cognitive trajectory in PD.
- Subjects :
- Age of Onset
Aged
Aged, 80 and over
Cognitive Dysfunction epidemiology
Female
Follow-Up Studies
Genotype
Humans
Kaplan-Meier Estimate
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Parkinson Disease epidemiology
Parkinson Disease physiopathology
Republic of Korea epidemiology
Retrospective Studies
Apolipoprotein E4 genetics
Apolipoproteins E genetics
Cognitive Dysfunction genetics
Disease Progression
Motor Activity genetics
Parkinson Disease genetics
Parkinson Disease psychology
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33837234
- Full Text :
- https://doi.org/10.1038/s41598-021-86483-w