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Effects of angiotensin II receptor blocker usage on viral load, antibody dynamics, and transcriptional characteristics among COVID-19 patients with hypertension.
- Source :
-
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2021 Apr 15; Vol. 22 (4), pp. 330-340. - Publication Year :
- 2021
-
Abstract
- Epidemiological evidence suggests that patients with hypertension infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at increased risk of acute lung injury. However, it is still not clear whether this increased risk is related to the usage of renin-angiotensin system (RAS) blockers. We collected medical records of coronavirus disease 2019 (COVID-19) patients from the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China), and evaluated the potential impact of an angiotensin II receptor blocker (ARB) on the clinical outcomes of COVID-19 patients with hypertension. A total of 30 hypertensive COVID-19 patients were enrolled, of which 17 were classified as non-ARB group and the remaining 13 as ARB group based on the antihypertensive therapies they received. Compared with the non-ARB group, patients in the ARB group had a lower proportion of severe cases and intensive care unit (ICU) admission as well as shortened length of hospital stay, and manifested favorable results in most of the laboratory testing. Viral loads in the ARB group were lower than those in the non-ARB group throughout the disease course. No significant difference in the time of seroconversion or antibody levels was observed between the two groups. The median levels of soluble angiotensin-converting enzyme 2 (sACE2) in serum and urine samples were similar in both groups, and there were no significant correlations between serum sACE2 and biomarkers of disease severity. Transcriptional analysis showed 125 differentially expressed genes which mainly were enriched in oxygen transport, bicarbonate transport, and blood coagulation. Our results suggest that ARB usage is not associated with aggravation of COVID-19. These findings support the maintenance of ARB treatment in hypertensive patients diagnosed with COVID-19.
- Subjects :
- Aged
Aged, 80 and over
Angiotensin Receptor Antagonists adverse effects
Angiotensin-Converting Enzyme 2 blood
Antihypertensive Agents adverse effects
Antihypertensive Agents therapeutic use
Biomarkers
China
Female
Humans
Hypertension complications
Intensive Care Units
Length of Stay
Male
Middle Aged
Retrospective Studies
Transcriptome
Angiotensin Receptor Antagonists therapeutic use
Antibodies, Viral blood
COVID-19 complications
Hypertension drug therapy
Viral Load
Subjects
Details
- Language :
- English
- ISSN :
- 1862-1783
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of Zhejiang University. Science. B
- Publication Type :
- Academic Journal
- Accession number :
- 33835767
- Full Text :
- https://doi.org/10.1631/jzus.B2000730