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Validation of a continuous measure of cardiometabolic risk among adolescents.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2021 Apr 07; Vol. 34 (6), pp. 763-770. Date of Electronic Publication: 2021 Apr 07 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Objectives: We validated a continuous cardiometabolic risk (CMR) measure among adolescents.<br />Methods: Five metabolic syndrome (MetS) components including waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting blood glucose, and mean arterial pressure were assessed in a national cohort of U.S. adolescents (n=560; 16.5 ± 0.5 y/o at baseline) in 10th grade (2010, Wave 1 (W1)), and follow-up assessments four (W4) and seven (W7) years later. Separately by wave, linear regressions were fitted to each MetS component controlling for age, sex, and race/ethnicity, and yielded standardized residuals (Z-scores). Wave-specific component Z-scores were summed to obtain composite CMR Z-scores. Four- and seven-year CMR change (CMR-diff W1-W4 and W1-W7). and average CMR risk (CMR-avg; (W1 + W4)/2 and (W1 + W7)/2) were calculated using the CMR Z-scores. W7 MetS was determined using adult criteria. Student's t-test and receiver operating characteristic (ROC) curve were conducted.<br />Results: Participants meeting the adult criteria for MetS at W7 (74 of 416, 17.8%) had statistically significant (p<0.01) higher values for W1 CMR Z-scores (0.92 vs. -0.21), W4 CMR Z-scores (1.69 vs. -0.28), W7 CMR Z-scores (2.21 vs. -0.55), W1-W4 CMR-avg (1.53 vs. -0.27), W1-W7 CMR-diff (1.29 vs. -0.21), and W1-W7 CMR-avg (1.46 vs. -0.48) than those not meeting MetS criteria. Most results were similar for males and females in the sex-stratified analyses. The areas under the ROC curve were 0.61, 0.71, and 0.75 for W1, W4 and W7 Z-scores.<br />Conclusions: Findings support the validity of the continuous CMR Z-scores calculated using linear regression in evaluating and monitoring CMR profiles from adolescence to early adulthood.<br /> (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
- Subjects :
- Adolescent
Adult
Blood Pressure
Cardiovascular Diseases etiology
Cardiovascular Diseases metabolism
Cholesterol, HDL blood
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Metabolic Syndrome etiology
Metabolic Syndrome metabolism
Prognosis
ROC Curve
Risk Factors
Triglycerides blood
Young Adult
Biomarkers blood
Body Mass Index
Cardiovascular Diseases pathology
Metabolic Syndrome pathology
Waist Circumference
Subjects
Details
- Language :
- English
- ISSN :
- 2191-0251
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 33823099
- Full Text :
- https://doi.org/10.1515/jpem-2020-0600