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ACTH(6-9)PGP Peptide Protects SH-SY5Y Cells from H 2 O 2 , tert -Butyl Hydroperoxide, and Cyanide Cytotoxicity via Stimulation of Proliferation and Induction of Prosurvival-Related Genes.

Authors :
Akimov MG
Fomina-Ageeva EV
Dudina PV
Andreeva LA
Myasoyedov NF
Bezuglov VV
Source :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 26; Vol. 26 (7). Date of Electronic Publication: 2021 Mar 26.
Publication Year :
2021

Abstract

Stabilized melanocortin analog peptide ACTH(6-9)PGP (HFRWPGP) possesses a wide range of neuroprotective activities. However, its mechanism of action remains poorly understood. In this paper, we present a study of the proproliferative and cytoprotective activity of the adrenocorticotropic hormone fragment 6-9 (HFRW) linked with the peptide prolyine-glycyl-proline on the SH-SY5Y cells in the model of oxidative stress-related toxicity. The peptide dose-dependently protected cells from H <subscript>2</subscript> O <subscript>2</subscript> , tert -butyl hydroperoxide, and KCN and demonstrated proproliferative activity. The mechanism of its action was the modulation of proliferation-related NF-κB genes and stimulation of prosurvival NRF2 -gene-related pathway, as well as a decrease in apoptosis.

Details

Language :
English
ISSN :
1420-3049
Volume :
26
Issue :
7
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
33810344
Full Text :
https://doi.org/10.3390/molecules26071878