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PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 12; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 12. - Publication Year :
- 2021
-
Abstract
- Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.
- Subjects :
- Aged
Animals
Arrhythmias, Cardiac physiopathology
Arrhythmias, Cardiac surgery
Female
Glycated Hemoglobin genetics
Heart Ventricles metabolism
Heart Ventricles pathology
Heart Ventricles surgery
Humans
Male
Middle Aged
Myocardial Infarction genetics
Myocardial Infarction pathology
Myocardial Infarction surgery
Non-ST Elevated Myocardial Infarction blood
Non-ST Elevated Myocardial Infarction genetics
Non-ST Elevated Myocardial Infarction physiopathology
Non-ST Elevated Myocardial Infarction surgery
Percutaneous Coronary Intervention adverse effects
Pituitary Adenylate Cyclase-Activating Polypeptide genetics
Risk Factors
ST Elevation Myocardial Infarction blood
ST Elevation Myocardial Infarction pathology
ST Elevation Myocardial Infarction surgery
Swine
Treatment Outcome
Troponin blood
Arrhythmias, Cardiac blood
Myocardial Infarction blood
Pituitary Adenylate Cyclase-Activating Polypeptide blood
ST Elevation Myocardial Infarction genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33809145
- Full Text :
- https://doi.org/10.3390/ijms22062883