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The Role of Single-Nucleotide Variants of NOS1 , NOS2, and NOS3 Genes in the Comorbidity of Arterial Hypertension and Tension-Type Headache.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 12; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 12. - Publication Year :
- 2021
-
Abstract
- Patients with tension-type headache (TTH) have an increased risk of developing arterial hypertension (AH), while hypertensive subjects do seem to have an increased risk of TTH. We searched for full-text English publications in databases using keywords and combined word searches over the past 15 years. In addition, earlier publications of historical interest were included in the review. In our review, we summed up the single nucleotide variants (SNVs) of Nitric Oxide Synthases ( NOSs ) genes involved in the development of essential AH and TTH. The results of studies we discussed in this review are contradictory. This might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical characteristics. However, the contribution of genetic and environmental factors remains understudied. This makes the issue interesting for researchers, as understanding these mechanisms can contribute to a search for new approaches to pathogenetic and disease-modifying treatment of the AH and TTH phenotype. New drugs against AH and TTH can be based on inhibition of nitric oxide (NO) production, blockade of steps in the NO-cGMP pathway, or NO scavenging. Indeed, selective neuronal NOS (n-NOS) and inducible NOS (i-NOS) inhibitors are already in early clinical development.
- Subjects :
- Comorbidity
Essential Hypertension epidemiology
Essential Hypertension physiopathology
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Male
Nitric Oxide metabolism
Polymorphism, Single Nucleotide
Tension-Type Headache epidemiology
Tension-Type Headache physiopathology
Essential Hypertension genetics
Nitric Oxide Synthase Type I genetics
Nitric Oxide Synthase Type II genetics
Nitric Oxide Synthase Type III genetics
Tension-Type Headache genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 33809023
- Full Text :
- https://doi.org/10.3390/molecules26061556