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Post-Transcriptional Regulation of Gnrhr : A Checkpoint for Metabolic Control of Female Reproduction.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 24; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 24. - Publication Year :
- 2021
-
Abstract
- The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern of expression through the estrous cycle in rodents, which is believed to be important for interpreting the finely tuned pulses of GnRH from the hypothalamus. Much work has shown that Gnrhr expression is heavily regulated at the level of transcription. However, researchers have also discovered that Gnrhr is regulated post-transcriptionally. This review will discuss how RNA-binding proteins and microRNAs may play critical roles in the regulation of GnRHR expression. We will also discuss how these post-transcriptional regulators may themselves be affected by metabolic cues, specifically with regards to the adipokine leptin. All together, we present evidence that Gnrhr is regulated post-transcriptionally, and that this concept must be further explored in order to fully understand the complex nature of this receptor.
- Subjects :
- 3' Untranslated Regions
Adipokines metabolism
Animals
Estrus
Female
Gonadotropin-Releasing Hormone metabolism
Humans
Leptin metabolism
Mice
Pituitary Gland metabolism
RNA, Messenger metabolism
Rats
Receptors, LHRH genetics
Transcription, Genetic
Gene Expression Regulation
Hypothalamus metabolism
Receptors, LHRH metabolism
Reproduction
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33805020
- Full Text :
- https://doi.org/10.3390/ijms22073312