Back to Search
Start Over
Fibrosis after Myocardial Infarction: An Overview on Cellular Processes, Molecular Pathways, Clinical Evaluation and Prognostic Value.
- Source :
-
Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2021 Mar 01; Vol. 9 (1). Date of Electronic Publication: 2021 Mar 01. - Publication Year :
- 2021
-
Abstract
- The ischemic injury caused by myocardial infarction activates a complex healing process wherein a powerful inflammatory response and a reparative phase follow and balance each other. An intricate network of mediators finely orchestrate a large variety of cellular subtypes throughout molecular signaling pathways that determine the intensity and duration of each phase. At the end of this process, the necrotic tissue is replaced with a fibrotic scar whose quality strictly depends on the delicate balance resulting from the interaction between multiple actors involved in fibrogenesis. An inflammatory or reparative dysregulation, both in term of excess and deficiency, may cause ventricular dysfunction and life-threatening arrhythmias that heavily affect clinical outcome. This review discusses cellular process and molecular signaling pathways that determine fibrosis and the imaging technique that can characterize the clinical impact of this process in-vivo.
- Subjects :
- Cicatrix
Fibrosis
Humans
Prognosis
Wound Healing
Myocardial Infarction diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 2076-3271
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medical sciences (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 33804308
- Full Text :
- https://doi.org/10.3390/medsci9010016