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Evaluation of the Effects of Developmental Trauma on Neurotransmitter Systems Using Functional Molecular Imaging.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 03; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 03. - Publication Year :
- 2021
-
Abstract
- Early life stress (ELS) is strongly associated with psychiatric disorders such as anxiety, depression, and schizophrenia in adulthood. To date, biological, behavioral, and structural aspects of ELS have been studied extensively, but their functional effects remain unclear. Here, we examined NeuroPET studies of dopaminergic, glutamatergic, and serotonergic systems in ELS animal models. Maternal separation and restraint stress were used to generate single or complex developmental trauma. Body weights of animals exposed to single trauma were similar to those of control animals; however, animals exposed to complex trauma exhibited loss of body weight when compared to controls. In behavioral tests, the complex developmental trauma group exhibited a decrease in time spent in the open arm of the elevated plus-maze and an increase in immobility time in the forced swim test when compared to control animals. In NeuroPET studies, the complex trauma group displayed a reduction in brain uptake values when compared to single trauma and control groups. Of neurotransmitter systems analyzed, the rate of decrease in brain uptake was the highest in the serotonergic group. Collectively, our results indicate that developmental trauma events induce behavioral deficits, including anxiety- and depressive-like phenotypes and dysfunction in neurotransmitter systems.
- Subjects :
- Animals
Animals, Newborn metabolism
Animals, Newborn physiology
Anxiety metabolism
Anxiety physiopathology
Anxiety Disorders metabolism
Anxiety Disorders physiopathology
Behavior, Animal physiology
Depression metabolism
Depression physiopathology
Disease Models, Animal
Exploratory Behavior physiology
Female
Male
Maternal Deprivation
Maze Learning physiology
Molecular Imaging methods
Rats
Rats, Sprague-Dawley
Stress, Psychological metabolism
Stress, Psychological physiopathology
Swimming physiology
Brain metabolism
Brain physiology
Neurotransmitter Agents metabolism
Wounds and Injuries metabolism
Wounds and Injuries physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33802338
- Full Text :
- https://doi.org/10.3390/ijms22052522