[Acupuncture combined with Heixiaoyao powder for children with cerebral palsy and its effect on serum immune indexes and nerve growth related protein].

Objective: To observe the efficacy of acupuncture combined with Heixiaoyao powder for children with cerebral palsy (liver- qi stagnation, spleen-kidney deficiency syndrome) and its effect on serum immune indexes and nerve growth related protein.
Methods: A total of 180 children with cerebral palsy were randomly divided into a combined group (60 cases, 2 cases dropped off), an acupuncture group (60 cases, 4 cases dropped off) and a Chinese medication group (60 cases, 5 cases dropped off). On the basis of conventional treatment, the children in the combined group were treated with acupuncture [Baihui (GV 20), Sishencong (EX-HN 1), Shenting (GV 24), Benshen (GB 13), 30 min each time, twice a day] and Heixiaoyao powder; the children in the acupuncture group were treated with acupuncture, and the children in the Chinese medication group were treated with Heixiaoyao powder, the treatment was same with the combined group. All the children were treated for 6 consecutive days and rest for 1 day, totaling for 8 weeks. The Gesell developmental schedules (GDS) and TCM symptom scores were recorded before treatment, after treatment and at 3-month, 6-month and 12-month follow-up visit; the serum immune indexes (IgA, IgG and IgM) and nerve growth related protein [myelin basic protein (MBP), high mobility group box-1 (HMGB ₁ ), neuronspecific enolase (NSE)] were detected before and after treatment. The clinical efficacy of each group was evaluated.
Results: The total effective rate was 91.4% (53/58) in the combined group, which was higher than 80.4% (45/56) in the acupuncture group and 78.2% (43/55) in the Chinese medication group ( P <0.05). Compared before treatment, the GDS scores in the three groups were increased and the TCM symptom scores were reduced after treatment and at 3-month, 6-month and 12-month follow-up visit ( P <0.05). The GDS score in the combined group was higher than that in the acupuncture group and the Chinese medication group, and the TCM symptom score was lower than that in the acupuncture group and Chinese medication group ( P <0.05). After treatment, the serum levels of IgA, IgG and IgM in the combined group were increased ( P <0.05), and the serum levels of MBP, HMGB _l and NSE were decreased ( P <0.05), and the improvements were superior to those in the acupuncture group and the Chinese medication group ( P <0.05).
Conclusion: Acupuncture combined with Heixiaoyao powder could effectively improve the development quotient in children with cerebral palsy (liver- qi stagnation, spleen-kidney deficiency syndrome), regulate the serum immune indexes and nerve growth related protein levels.