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Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos.
- Source :
-
Protein & cell [Protein Cell] 2021 Sep; Vol. 12 (9), pp. 741-745. Date of Electronic Publication: 2021 Apr 01. - Publication Year :
- 2021
- Subjects :
- Animals
Bacterial Proteins metabolism
Blastomeres cytology
CRISPR-Associated Proteins metabolism
DNA Cleavage
DNA, Single-Stranded chemistry
DNA, Single-Stranded metabolism
Embryo Transfer
Embryo, Mammalian
Endodeoxyribonucleases metabolism
Genes, Reporter
Genetic Therapy methods
Genetic Therapy trends
Green Fluorescent Proteins genetics
Green Fluorescent Proteins metabolism
INDEL Mutation
Mice
Polymorphism, Single Nucleotide
Whole Genome Sequencing
Bacterial Proteins genetics
Blastomeres metabolism
CRISPR-Associated Proteins genetics
CRISPR-Cas Systems
DNA, Single-Stranded genetics
Endodeoxyribonucleases genetics
Gene Editing methods
Genome
Subjects
Details
- Language :
- English
- ISSN :
- 1674-8018
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Protein & cell
- Publication Type :
- Editorial & Opinion
- Accession number :
- 33797032
- Full Text :
- https://doi.org/10.1007/s13238-021-00824-z