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TS-HDS and FGFR3 antibodies in small fiber neuropathy and Dysautonomia.
- Source :
-
Muscle & nerve [Muscle Nerve] 2021 Jul; Vol. 64 (1), pp. 70-76. Date of Electronic Publication: 2021 Apr 15. - Publication Year :
- 2021
-
Abstract
- Introduction: The specificity of trisulfated heparin disaccharide/fibroblast growth factor receptor 3 (TS-HDS/FGFR3) antibodies in the diagnosis of autoimmune small fiber neuropathy (SFN) is unclear.<br />Methods: This was a retrospective study of patients evaluated for SFN and dysautonomia in the Brigham and Women's Faulkner Hospital Autonomic Laboratory in 2019-2020. Associations were assessed between TS-HDS/FGFR3 antibodies and SFN markers, including epidermal nerve fiber density (ENFD), sweat gland nerve fiber density (SGNFD), and autonomic dysfunction assessed by Valsalva maneuver, deep breathing, sudomotor, and tilt testing.<br />Results: Of 322 patients; 28% had elevated anti-TS-HDS, 17% had elevated anti-FGFR3, 96% had autonomic dysfunction, 71% had abnormal ENFD, and 49% had abnormal SGNFD. TS-HDS/FGFR3 antibodies were present in patients with autonomic dysfunction irrespective of whether they had normal or abnormal skin biopsies unless ENFD/SGNFD were combined for anti-FGFR3 seropositivity.<br />Discussion: TS-HDS/FGFR3 antibodies are present in patients with evidence of autonomic dysfunction. Further studies are needed to document the clinical value of these antibodies in assessment of immune mediated dysautonomia.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Adult
Biomarkers blood
Female
Heparin blood
Humans
Male
Middle Aged
Primary Dysautonomias diagnosis
Retrospective Studies
Small Fiber Neuropathy diagnosis
Autoantibodies blood
Disaccharides blood
Heparin analogs & derivatives
Primary Dysautonomias blood
Receptor, Fibroblast Growth Factor, Type 3 blood
Small Fiber Neuropathy blood
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 64
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 33792960
- Full Text :
- https://doi.org/10.1002/mus.27245