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Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated Apc Min/+ Mice.
- Source :
-
Anticancer research [Anticancer Res] 2021 Mar; Vol. 41 (3), pp. 1299-1305. - Publication Year :
- 2021
-
Abstract
- Background/aim: A xanthophyll of fucoxanthin (Fx) is a potential chemopreventive agent. Familial adenomatous polyposis (FAP) is an inherited disease that is associated with a high risk of developing colorectal cancer. However, it remains unclear whether Fx can modify colorectal tumorigenesis in Apc <superscript>Min/+</superscript> mice, a model mouse for human FAP.<br />Materials and Methods: We investigated the chemopreventive effect of Fx in dextran sodium sulfate (DSS)-treated Apc <superscript>Min/+</superscript> mice.<br />Results: Administration of Fx in the diet for 5 weeks significantly suppressed the number of colorectal adenocarcinomas in DSS-treated male Apc <superscript>Min/+</superscript> mice, although the treatment did not affect the occurrence of colorectal dysplastic crypts and adenoma in the mice. In addition, Fx down-regulated cyclin D1 expression (0.6-fold) in colorectal mucosa of Apc <superscript>Min/+</superscript> mice when compared with that of the control mice.<br />Conclusion: Fx possesses chemopreventive potential against progression of colorectal carcinogenesis in Apc <superscript>Min/+</superscript> mice that receive inflammatory stimuli.<br /> (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Animals
Colorectal Neoplasms chemically induced
Cyclin D1 analysis
Cyclin D1 physiology
Dextran Sulfate
Disease Models, Animal
Male
Mice
Adenomatous Polyposis Coli complications
Anticarcinogenic Agents administration & dosage
Colorectal Neoplasms prevention & control
Xanthophylls administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 33788721
- Full Text :
- https://doi.org/10.21873/anticanres.14887