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Imaging methods in mechanosensing: a historical perspective and visions for the future.
- Source :
-
Molecular biology of the cell [Mol Biol Cell] 2021 Apr 19; Vol. 32 (9), pp. 842-854. Date of Electronic Publication: 2021 Mar 31. - Publication Year :
- 2021
-
Abstract
- Over the past three decades, as mechanobiology has become a distinct area of study, researchers have developed novel imaging tools to discover the pathways of biomechanical signaling. Early work with substrate engineering and particle tracking demonstrated the importance of cell-extracellular matrix interactions on the cell cycle as well as the mechanical flux of the intracellular environment. Most recently, tension sensor approaches allowed directly measuring tension in cell-cell and cell-substrate interactions. We retrospectively analyze how these various optical techniques progressed the field and suggest our vision forward for a unified theory of cell mechanics, mapping cellular mechanosensing, and novel biomedical applications for mechanobiology.
Details
- Language :
- English
- ISSN :
- 1939-4586
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Molecular biology of the cell
- Publication Type :
- Academic Journal
- Accession number :
- 33788578
- Full Text :
- https://doi.org/10.1091/mbc.E20-10-0671