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Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis.
- Source :
-
Surgery today [Surg Today] 2021 Nov; Vol. 51 (11), pp. 1860-1871. Date of Electronic Publication: 2021 Mar 31. - Publication Year :
- 2021
-
Abstract
- Purpose: Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments. The cause of death is mostly sepsis-induced multiple organ failure. Oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established.<br />Methods: Two experiments were performed. In the first experiment, we confirmed the effects of peritoneal lavage with hydrogen-rich saline (HRS) after a cecal ligation and puncture (CLP) operation in rats. In the second experiment, the changes in the hemodynamic state following this procedure were observed in a porcine model of abdominal sepsis to evaluate its safety and utility.<br />Results: Peritoneal lavage with HRS significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure. Moreover, it showed anti-inflammatory and anti-apoptosis as well as antioxidant effects. The second experiment demonstrated the potential safety and feasibility of this procedure in a large animal model.<br />Conclusion: This procedure can improve survival after sepsis through mitigating the sepsis-induced organ failure by inhibiting oxidative stress, apoptosis, and inflammatory pathways. Peritoneal lavage with HRS may therefore be an effective, safe, and practical therapy for patients with acute peritonitis.<br /> (© 2021. Springer Nature Singapore Pte Ltd.)
- Subjects :
- Acute Disease
Animals
Disease Models, Animal
Male
Oxidative Stress
Peritonitis etiology
Rats, Inbred F344
Reactive Oxygen Species
Sepsis etiology
Treatment Outcome
Rats
Antioxidants administration & dosage
Free Radical Scavengers administration & dosage
Hydrogen administration & dosage
Peritoneal Lavage methods
Peritonitis therapy
Saline Solution administration & dosage
Sepsis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1436-2813
- Volume :
- 51
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Surgery today
- Publication Type :
- Academic Journal
- Accession number :
- 33787966
- Full Text :
- https://doi.org/10.1007/s00595-021-02271-z