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Significance of PD-L1 expression in the cytological samples of non-small cell lung cancer patients treated with immune checkpoint inhibitors.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Dec; Vol. 147 (12), pp. 3749-3755. Date of Electronic Publication: 2021 Mar 29. - Publication Year :
- 2021
-
Abstract
- Objectives: The programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) in tumor tissue samples is an established clinical biomarker for non-small cell lung cancer (NSCLC). However, the significance of PD-L1 expression in other types of samples has not been fully investigated.<br />Patients and Methods: We conducted a multicenter retrospective cohort study of advanced NSCLC patients who received ICI treatment during the clinical course and investigated the effects of ICIs according to PD-L1 expression in cytology samples, including cell block and endobronchial ultrasound-guided (EBUS) transbronchial needle aspiration (TBNA) samples.<br />Results: A total of 264 patients were included in this study: PD-L1 expression was determined in cell block or TBNA specimens in 55 patients, and in tissue samples in 209 patients. Among the former patients, the median progression-free survival (PFS) of those with a TPS for PD-L1 ≥ 50% was significantly longer compared to that of those with a TPS < 50% (6.5 vs. 1.9 months, respectively, p = 0.008). When the cutoff value was set at 1%, the median PFS was 4.2 months in patients with a TPS ≥ 1% and 1.5 months in patients with a TPS < 1% (p < 0.001).<br />Conclusion: PD-L1 expression determined using cytology specimens predicts the efficacy of ICIs.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor metabolism
Body Fluids
Cohort Studies
Cytodiagnosis methods
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Female
Humans
Male
Middle Aged
Retrospective Studies
Treatment Outcome
B7-H1 Antigen analysis
Biomarkers, Tumor analysis
Carcinoma, Non-Small-Cell Lung drug therapy
Immune Checkpoint Inhibitors therapeutic use
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 147
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 33779840
- Full Text :
- https://doi.org/10.1007/s00432-021-03615-5