Coronary CT Angiography-derived Fractional Flow Reserve Testing in Patients with Stable Coronary Artery Disease: Recommendations on Interpretation and Reporting.

Noninvasive fractional flow reserve derived from coronary CT angiography (FFR _CT ) is increasingly used in patients with coronary artery disease as a gatekeeper to the catheterization laboratory. While there is emerging evidence of the clinical benefit of FFR _CT in patients with moderate coronary disease as determined with coronary CT angiography, there has been less focus on interpretation, reporting, and integration of FFR _CT results into routine clinical practice. Because FFR _CT analysis provides a plethora of information regarding pressure and flow across the entire coronary tree, standardized criteria on interpretation and reporting of the FFR _CT analysis result are of crucial importance both in context of the clinical adoption and in future research. This report represents expert opinion and recommendation on a standardized FFR _CT interpretation and reporting approach. Published under a CC BY 4.0 license.
Competing Interests: Disclosures of Conflicts of Interest: B.L.N. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: has received unrestricted institutional research grants from Siemens and HeartFlow; travel expenses covered at TCT 2017 by HeartFlow (no personal payment). Other relationships: disclosed no relevant relationships. T.A.F. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: has been an invited speaker sponsored by HeartFlow. Other relationships: disclosed no relevant relationships. R.D.S. disclosed no relevant relationships. M.G.R. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: author is consultant for HeartFlow. Other relationships: disclosed no relevant relationships. B.K. Activities related to the present article: has been an invited speaker at symposiums sponsored by Canon Medical, Medtronic, and St Jude, and has received research funding from Canon Medical. Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. J.M.J. disclosed no relevant relationships. K.N. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: unrestricted institutional research support from HeartFlow, Siemens, GE, and Bayer; coverage of travel expenses to the present study results at the TCT in 2018 by HeartFlow; Steering committee ADVANCE registry for HeartFlow (unpaid). Other relationships: disclosed no relevant relationships. K.M.C. Activities related to the present article: institution receives grant from HeartFlow. Activities not related to the present article: Medical Advisory Board for HeartFlow (no personal compensation); institution receives grants from HeartFlow. Other relationships: disclosed no relevant relationships. N.P.S. disclosed no relevant relationships. H.M. disclosed no relevant relationships. J.L. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: has received speaker honoraria from GE Healthcare, served as a consultant for Edwards Lifesciences, and served as a consultant and has stock options in Circle CVI and HeartFlow; has core laboratory contracts with Edwards Lifesciences, Medtronic, Abbott, Noevasc; research support from Edwards. Other relationships: disclosed no relevant relationships. G.R. disclosed no relevant relationships.
(2019 by the Radiological Society of North America, Inc.)