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Genomic markers associated with successful treatment of hypertension with lisinopril: A pilot study.
- Source :
-
International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2021 Jul; Vol. 59 (7), pp. 506-510. - Publication Year :
- 2021
-
Abstract
- Objective: To identify single nucleotide variants (SNVs) associated with lisinopril effectiveness.<br />Materials and Methods: This was an observational study using a candidate gene approach to examine SNVs associated with lisinopril effectiveness. Drug effectiveness was defined as 10% decrease in systolic blood pressure at 1 week follow-up. We used the Illumina GWAS MEGA chip to examine variants in the renin/angiotensin pathway that may be associated with drug effectiveness.<br />Results: 61 subjects were enrolled, and 33 (54.1%) were responsive to lisinopril therapy. SNVs in AGT (p = 0.0141), REN (p = 0.0192), and ACE2 (p = 0.0002) were found to be associated with successful treatment on lisinopril. Conclusion and relevance: SNVs in the renin and angiotensin pathway are associated with lisinopril effectiveness in a pilot cohort of patients with uncontrolled hypertension.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors pharmacology
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antihypertensive Agents pharmacology
Antihypertensive Agents therapeutic use
Blood Pressure
Genomics
Humans
Pilot Projects
Renin-Angiotensin System
Hypertension drug therapy
Hypertension genetics
Lisinopril pharmacology
Lisinopril therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0946-1965
- Volume :
- 59
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 33769277
- Full Text :
- https://doi.org/10.5414/CP203910