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Effects of Lactobacillus reuteri supplementation on the gut microbiota in extremely preterm infants in a randomized placebo-controlled trial.
- Source :
-
Cell reports. Medicine [Cell Rep Med] 2021 Feb 22; Vol. 2 (3), pp. 100206. Date of Electronic Publication: 2021 Feb 22 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Extremely low birth weight (ELBW) infants often develop an altered gut microbiota composition, which is related to clinical complications, such as necrotizing enterocolitis and sepsis. Probiotic supplementation may reduce these complications, and modulation of the gut microbiome is a potential mechanism underlying the probiotic effectiveness. In a randomized, double-blind, placebo-controlled trial, we assessed the effect of Lactobacillus reuteri supplementation, from birth to post-menstrual week (PMW)36, on infant gut microbiota. We performed 16S amplicon sequencing in 558 stool samples from 132 ELBW preterm infants at 1 week, 2 weeks, 3 weeks, 4 weeks, PMW36, and 2 years. Probiotic supplementation results in increased bacterial diversity and increased L. reuteri abundance during the 1 <superscript>st</superscript> month. At 1 week, probiotic supplementation also results in a lower abundance of Enterobacteriaceae and Staphylococcaceae. No effects were found at 2 years. In conclusion, probiotics may exert benefits by modulating the gut microbiota composition during the 1 <superscript>st</superscript> month in ELBW infants.<br />Competing Interests: T.A. has received honoraria for lectures and a grant for the present trial from BioGaia AB. M.C.J. has received honoraria for lectures from BioGaia AB. E.S.-E. has received honoraria for lectures and a research grant from BioGaia AB.<br /> (© 2021 The Author(s).)
- Subjects :
- Actinobacteria classification
Actinobacteria genetics
Actinobacteria isolation & purification
Bacteroidetes classification
Bacteroidetes genetics
Bacteroidetes isolation & purification
Biodiversity
Feces microbiology
Female
Firmicutes classification
Firmicutes genetics
Firmicutes isolation & purification
Fusobacteria classification
Fusobacteria genetics
Fusobacteria isolation & purification
Humans
Infant
Male
Proteobacteria classification
Proteobacteria genetics
Proteobacteria isolation & purification
RNA, Ribosomal, 16S genetics
Verrucomicrobia classification
Verrucomicrobia genetics
Verrucomicrobia isolation & purification
Dietary Supplements
Gastrointestinal Microbiome genetics
Infant, Extremely Low Birth Weight growth & development
Infant, Extremely Premature growth & development
Limosilactobacillus reuteri physiology
Probiotics administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2666-3791
- Volume :
- 2
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell reports. Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33763652
- Full Text :
- https://doi.org/10.1016/j.xcrm.2021.100206