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High KIFC1 expression is associated with poor prognosis in prostate cancer.

Authors :
Kostecka LG
Olseen A
Kang K
Torga G
Pienta KJ
Amend SR
Source :
Medical oncology (Northwood, London, England) [Med Oncol] 2021 Mar 24; Vol. 38 (5), pp. 47. Date of Electronic Publication: 2021 Mar 24.
Publication Year :
2021

Abstract

Kinesins play important roles in the progression and development of cancer. Kinesin family member C1 (KIFC1), a minus end-directed motor protein, is a novel Kinesin involved in the clustering of excess centrosomes found in cancer cells. Recently KIFC1 has shown to play a role in the progression of many different cancers, however, the involvement of KIFC1 in the progression of prostate cancer (PCa) is still not well understood. This study investigated the expression and clinical significance of KIFC1 in PCa by utilizing multiple publicly available datasets to analyze KIFC1 expression in patient samples. High KIFC1 expression was found to be associated with high Gleason score, high tumor stage, metastatic lesions, high ploidy levels, and lower recurrence-free survival. These results reveal that high KIFC1 levels are associated with a poor prognosis for PCa patients and could act as a prognostic indicator for PCa patients as well.

Details

Language :
English
ISSN :
1559-131X
Volume :
38
Issue :
5
Database :
MEDLINE
Journal :
Medical oncology (Northwood, London, England)
Publication Type :
Academic Journal
Accession number :
33760984
Full Text :
https://doi.org/10.1007/s12032-021-01494-x