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[The quantitative identification of metabolites of dihydralazine in the human].

Authors :
Schneider T
Siegmund W
Zschiesche M
Kallwellis R
Scherber A
Source :
Die Pharmazie [Pharmazie] 1988 Jan; Vol. 43 (1), pp. 33-6.
Publication Year :
1988

Abstract

The metabolism of dihydralazine sulfate was studied in 11 hypertonic patients treated with that drug chronically. The metabolites were identified in urine with gc, dc, and hplc by comparison with synthesized reference compounds. Following metabolites could be verified: acetylated products, oxidation products, hydrazones and products of decomposition. Products resulting from reaction with nitrites could be not detected.

Details

Language :
German
ISSN :
0031-7144
Volume :
43
Issue :
1
Database :
MEDLINE
Journal :
Die Pharmazie
Publication Type :
Academic Journal
Accession number :
3375299