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Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis - data from the German AID-registry.
- Source :
-
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2021 Mar 22; Vol. 19 (1), pp. 38. Date of Electronic Publication: 2021 Mar 22. - Publication Year :
- 2021
-
Abstract
- Background: Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinflammatory character of the disease and offering an effective blocking mechanism for treatment. Here we present clinical practice data from the German AID-registry for patients treated with IL-1 inhibition (IL-1i).<br />Methods: In 2009 a clinical and research consortium (AID-Net) was established, including an online AID-registry. Patients with documented sJIA diagnosis were identified. Data for this retrospective IL-1i study were recorded by 17 centers. Response to treatment was evaluated according to Wallace criteria and additionally by an own classifying clinical response system.<br />Results: In 6 years, 202 patients with confirmed sJIA were recorded in the AID-registry. Out of these, 111 children received therapy with Anakinra (ANA) (n = 84, 39 f) and/or Canakinumab (CANA) (n = 27, 15 f) at a median age of 8.7 y (range 0.6-19.1). During the first 12 months 75/111 (ANA 55, CANA 20) patients were evaluated according to Wallace criteria (achievement of inactive disease 28/55 and 17/20, remission over 6 months under medication 13/55 and 7/20 cases). Over the whole period of time, clinical response was preserved in the majority of patients (ANA 54/80, CANA 20/27). Arthritis mostly persisted in polyarticular (PA) courses. During treatment with IL-1i concomitant medication could be tapered in about 15%. IL-1i was discontinued in 59/111 patients. 45 (15) adverse events (AE)s in ANA (CANA) treated patients (19.7 (26.6) AE/100 ANA (CANA) exposure years, 95%CI: 14.4-26.4 (14.9-43.9)) were reported.<br />Conclusion: In a large cohort of sJIA patients from Germany, we can confirm an overall favorable clinical response to both available IL-1 blocking agents. IL-1i was well tolerated with acceptable safety and effectiveness in a real-life clinical setting.
- Subjects :
- Adolescent
Child
Child, Preschool
Germany
Humans
Infant
Registries
Retrospective Studies
Young Adult
Antibodies, Monoclonal, Humanized therapeutic use
Antirheumatic Agents therapeutic use
Arthritis, Juvenile drug therapy
Interleukin 1 Receptor Antagonist Protein therapeutic use
Interleukin-1beta antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1546-0096
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pediatric rheumatology online journal
- Publication Type :
- Academic Journal
- Accession number :
- 33752669
- Full Text :
- https://doi.org/10.1186/s12969-021-00510-8