Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases.

Calcium (Ca ²⁺ ) is a second messenger essential for cellular homeostasis. Inside the cell, Ca ²⁺ is compartmentalized and exchanged among organelles in response to both external and internal stimuli. Mitochondria-associated membranes (MAMs) provide a platform for proteins and channels involved in Ca ²⁺ transfer between the endoplasmic reticulum (ER) and mitochondria. Deregulated Ca ²⁺ signaling and proteins regulating ER-mitochondria interactions have been linked to liver diseases and intensively investigated in recent years. In this review, we summarize the role of MAM-resident proteins in Ca ²⁺ transfer and their association with different liver diseases.
(© 2021 Federation of European Biochemical Societies.)