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Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area.
- Source :
-
JCI insight [JCI Insight] 2021 Mar 22; Vol. 6 (6). Date of Electronic Publication: 2021 Mar 22. - Publication Year :
- 2021
-
Abstract
- The early COVID-19 pandemic was characterized by rapid global spread. In Maryland and Washington, DC, United States, more than 2500 cases were reported within 3 weeks of the first COVID-19 detection in March 2020. We aimed to use genomic sequencing to understand the initial spread of SARS-CoV-2 - the virus that causes COVID-19 - in the region. We analyzed 620 samples collected from the Johns Hopkins Health System during March 11-31, 2020, comprising 28.6% of the total cases in Maryland and Washington, DC. From these samples, we generated 114 complete viral genomes. Analysis of these genomes alongside a subsampling of over 1000 previously published sequences showed that the diversity in this region rivaled global SARS-CoV-2 genetic diversity at that time and that the sequences belong to all of the major globally circulating lineages, suggesting multiple introductions into the region. We also analyzed these regional SARS-CoV-2 genomes alongside detailed clinical metadata and found that clinically severe cases had viral genomes belonging to all major viral lineages. We conclude that efforts to control local spread of the virus were likely confounded by the number of introductions into the region early in the epidemic and the interconnectedness of the region as a whole.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Baltimore
Base Sequence
COVID-19 epidemiology
COVID-19 transmission
Child
Disease Outbreaks
Disease Transmission, Infectious
District of Columbia
Female
Genomics methods
Global Health
Humans
Male
Middle Aged
Young Adult
COVID-19 virology
Genome, Viral
Pandemics
Phylogeny
SARS-CoV-2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2379-3708
- Volume :
- 6
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- JCI insight
- Publication Type :
- Academic Journal
- Accession number :
- 33749660
- Full Text :
- https://doi.org/10.1172/jci.insight.144350