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circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2021 Oct; Vol. 236 (10), pp. 6793-6805. Date of Electronic Publication: 2021 Mar 21. - Publication Year :
- 2021
-
Abstract
- Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR-7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR-7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Animals
Basic Helix-Loop-Helix Transcription Factors genetics
Cell Line
Gene Expression Regulation
Mice
MicroRNAs genetics
RNA, Circular genetics
Signal Transduction
Basic Helix-Loop-Helix Transcription Factors metabolism
Cell Differentiation
Cell Proliferation
MicroRNAs metabolism
Muscle Development
Myoblasts, Skeletal metabolism
RNA, Circular metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 236
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 33748999
- Full Text :
- https://doi.org/10.1002/jcp.30363