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To treat or not to treat: CFTR modulators after lung transplantation.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2021 Jun; Vol. 25 (4), pp. e14007. Date of Electronic Publication: 2021 Mar 20. - Publication Year :
- 2021
-
Abstract
- Evidence for the extrapulmonary benefits of (CFTR) modulators is rapidly expanding. The use of CFTR modulators in CF patients who have undergone lung transplantation is not clear without guidance published in the medical literature to assist clinicians in the care of these patients. We discuss the potential benefits of CFTR modulators and provide insight into their use based on our experience in a small cohort of CF LTx recipients. We present pros and cons of CFTR modulator therapy for LTx recipients with CF. CFTR modulators should be considered in CF patients after lung transplantation for the time being until further research defines how to best use these therapies in transplant recipients.<br /> (© 2021 Wiley Periodicals LLC.)
- Subjects :
- Adolescent
Biomarkers metabolism
Combined Modality Therapy
Cystic Fibrosis genetics
Cystic Fibrosis metabolism
Cystic Fibrosis Transmembrane Conductance Regulator genetics
Drug Combinations
Humans
Treatment Outcome
Young Adult
Aminophenols therapeutic use
Benzodioxoles therapeutic use
Cystic Fibrosis drug therapy
Cystic Fibrosis surgery
Cystic Fibrosis Transmembrane Conductance Regulator metabolism
Indoles therapeutic use
Lung Transplantation
Postoperative Care methods
Pyrazoles therapeutic use
Pyridines therapeutic use
Quinolines therapeutic use
Quinolones therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 33742748
- Full Text :
- https://doi.org/10.1111/petr.14007