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Prediction of stimulus-independent and task-unrelated thought from functional brain networks.
- Source :
-
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1793. Date of Electronic Publication: 2021 Mar 19. - Publication Year :
- 2021
-
Abstract
- Neural substrates of "mind wandering" have been widely reported, yet experiments have varied in their contexts and their definitions of this psychological phenomenon, limiting generalizability. We aimed to develop and test the generalizability, specificity, and clinical relevance of a functional brain network-based marker for a well-defined feature of mind wandering-stimulus-independent, task-unrelated thought (SITUT). Combining functional MRI (fMRI) with online experience sampling in healthy adults, we defined a connectome-wide model of inter-regional coupling-dominated by default-frontoparietal control subnetwork interactions-that predicted trial-by-trial SITUT fluctuations within novel individuals. Model predictions generalized in an independent sample of adults with attention-deficit/hyperactivity disorder (ADHD). In three additional resting-state fMRI studies (total nā=ā1115), including healthy individuals and individuals with ADHD, we demonstrated further prediction of SITUT (at modest effect sizes) defined using multiple trait-level and in-scanner measures. Our findings suggest that SITUT is represented within a common pattern of brain network interactions across time scales and contexts.
- Subjects :
- Adolescent
Adult
Attention Deficit Disorder with Hyperactivity physiopathology
Brain physiology
Cohort Studies
Female
Humans
Male
Middle Aged
Nerve Net physiology
Neural Pathways diagnostic imaging
Neural Pathways physiology
Neuropsychological Tests
Rest physiology
Young Adult
Attention Deficit Disorder with Hyperactivity diagnostic imaging
Brain diagnostic imaging
Connectome methods
Magnetic Resonance Imaging methods
Nerve Net diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 33741956
- Full Text :
- https://doi.org/10.1038/s41467-021-22027-0