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Retinal ganglion cell dysfunction in preclinical Alzheimer's disease: an electrophysiologic biomarker signature.
- Source :
-
Scientific reports [Sci Rep] 2021 Mar 18; Vol. 11 (1), pp. 6344. Date of Electronic Publication: 2021 Mar 18. - Publication Year :
- 2021
-
Abstract
- The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer's disease (AD), as classified by cerebral spinal fluid (CSF) Aβ <subscript>42</subscript> /Tau ratio. Individuals with normal retinal morphology ascertained by spectral-domain optical coherence tomography were enrolled. Full-field ERG, pattern PERG, and photopic negative response (PhNR) were performed in 29 adult participants (58 eyes). Amplitude and implicit times of the ERG wave components were analyzed. Preclinical AD participants showed marked retinal ganglion cell dysfunction relative to controls. The PhNR was significantly diminished in preclinical AD relative to controls. PhNR amplitude and N95 implicit time differentiated CH individuals with CSF biomarkers of AD pathology with 87% sensitivity and 82% specificity. These quantitative electrophysiologic findings expand our understanding of early retinal functional changes that precede cognitive decline in AD. Retinal ganglion cell dysfunction, as detected by ERG, may be a clinically useful, non-invasive in vivo biomarker for early disease detection, which is necessary for ultimately pursuing early intervention.
- Subjects :
- Aged
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease complications
Alzheimer Disease pathology
Biomarkers cerebrospinal fluid
Electrophysiological Phenomena
Electroretinography
Humans
Middle Aged
Nerve Fibers pathology
Neuropsychological Tests
Photic Stimulation
Retina metabolism
Retina pathology
Retinal Diseases cerebrospinal fluid
Retinal Diseases complications
Retinal Diseases pathology
Retinal Ganglion Cells pathology
Tomography, Optical Coherence
Visual Fields
Alzheimer Disease diagnostic imaging
Amyloid beta-Peptides cerebrospinal fluid
Peptide Fragments cerebrospinal fluid
Retina diagnostic imaging
Retinal Diseases diagnostic imaging
tau Proteins cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33737516
- Full Text :
- https://doi.org/10.1038/s41598-021-85010-1