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Phytochemicals against SARS-CoV as potential drug leads.

Authors :
Swain SS
Panda SK
Luyten W
Source :
Biomedical journal [Biomed J] 2021 Mar; Vol. 44 (1), pp. 74-85. Date of Electronic Publication: 2020 Dec 10.
Publication Year :
2021

Abstract

The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the health emergency, repurposing of existing antiviral, antiinflammatory or antimalarial drugs is an attractive option for controlling SARS-CoV-2 with drugs. However, phytochemicals selected based on ethnomedicinal information as well as in vitro antiviral studies could be promising as well. Here, we summarise the phytochemicals with reported anti-CoV activity, and further analyzed them computationally to accelerate validation for drug development against SARS-CoV-2. This systematic review started from the most potent phytocompounds (IC <subscript>50</subscript> in μM) against SARS-CoV, followed by a cluster analysis to locate the most suitable lead(s). The advanced molecular docking used the crystallography structure of SARS-CoV-2-cysteine-like protease (SARS-CoV-2-3CL <superscript>pro</superscript> ) as a target. In total, seventy-eight phytochemicals with anti-CoV activity against different strains in cellular assays, were selected for this computational study, and compared with two existing repurposed FDA-approved drugs: lopinavir and ritonavir. This review brings insights in the potential application of phytochemicals and their derivatives, which could guide researchers to develop safe drugs against SARS-CoV-2.<br />Competing Interests: Conflicts of interest The authors declare no conflicts of interest.<br /> (Copyright © 2020 Chang Gung University. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
2320-2890
Volume :
44
Issue :
1
Database :
MEDLINE
Journal :
Biomedical journal
Publication Type :
Academic Journal
Accession number :
33736953
Full Text :
https://doi.org/10.1016/j.bj.2020.12.002