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The Role of CXCL13 in Antibody Responses to HIV-1 Infection and Vaccination.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Feb 25; Vol. 12, pp. 638872. Date of Electronic Publication: 2021 Feb 25 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- CXCL13 signals through the G protein-coupled chemokine receptor CXCR5 to drive development of secondary lymphoid tissue as well as B cell and Tfh cell trafficking to germinal centers (GC), which leads to the differentiation of B cells to plasma cells and memory B cells. CXCL13 has been proposed as a general plasma biomarker for GC activities. In HIV-1 infected individuals, plasma CXCL13 levels have been associated with the rate of disease progression to AIDS. Moreover, CXCL13 production has been reported to be increased in HIV-1-infected lymph nodes, which may drive increased downregulation of CXCR5. In this review, we address the role of CXCL13 in HIV-1 infected individuals with regard to GC formation, generation of broadly neutralizing antibodies after infection and vaccination, and AIDS-related B cell lymphoma.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Bekele Feyissa, Chiodi, Sui and Berzofsky.)
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33732259
- Full Text :
- https://doi.org/10.3389/fimmu.2021.638872