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A Randomized, Evaluator-Blind, Split-Face Study Evaluating the Safety and Efficacy of Calcium Hydroxylapatite for Jawline Augmentation.
- Source :
-
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2022 Jan 01; Vol. 48 (1), pp. 76-81. - Publication Year :
- 2022
-
Abstract
- Introduction: Jawline augmentation with calcium hydroxylapatite has not yet been evaluated in a prospective study with a split-face design. This study aims to perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique.<br />Objective: To perform the first randomized controlled, split-face study on the efficacy and safety of calcium hydroxylapatite for jawline augmentation using the needle and cannula technique.<br />Materials and Methods: This is a single-site, randomized, evaluator-blind trial enrolling a total of 10 healthy subjects with at least Grade 1 (mild) on a 4-point Jawline Scale. One side of the face was randomized to receive 1 to 2 syringes of calcium hydroxylapatite with lidocaine (total of 3 mL) for correction of wrinkles and folds along the jawline using both the cannula and needle method, and a balancing treatment will be performed 1 month later. Blinded investigator and subject evaluations will be performed immediately after treatment and at the 30-, 60-, and 90-day visits.<br />Results: Ten subjects were enrolled and completed the trial. There was a improvement in the degree of wrinkling and skin sagging in the 4-point Jawline Scale, with an average of a 1.3-point improvement in the scale on the day of treatment and at the Day 30 visit, which remained improved greater than baseline after 3 months as graded by blinded investigators. The Clinician Global Aesthetic Improvement Score for the treated side versus control, as assessed by blinded investigators, demonstrated a improvement with a 2.3-point improvement on the 5-point scale, and by the final visit on Day 90, most patients had a much improved appearance from baseline.<br />Conclusion: This study demonstrates that calcium hydroxylapatite is effective and safe for restoration and augmentation of the jawline using the unique needle and cannula technique.<br /> (Copyright © 2020 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Cannula
Dermal Fillers adverse effects
Durapatite adverse effects
Esthetics
Female
Healthy Volunteers
Humans
Injections, Subcutaneous instrumentation
Injections, Subcutaneous methods
Lidocaine administration & dosage
Lidocaine adverse effects
Male
Middle Aged
Needles
Patient Satisfaction
Pilot Projects
Prospective Studies
Rhytidoplasty adverse effects
Treatment Outcome
Young Adult
Dermal Fillers administration & dosage
Durapatite administration & dosage
Rhytidoplasty methods
Skin Aging drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4725
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
- Publication Type :
- Academic Journal
- Accession number :
- 33731569
- Full Text :
- https://doi.org/10.1097/DSS.0000000000002582