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Computational Insight into Cu-Catalyzed C sp -S Coupling to Form a Macrocyclic Alkynyl Sulfide.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2021 Apr 02; Vol. 86 (7), pp. 5120-5128. Date of Electronic Publication: 2021 Mar 17. - Publication Year :
- 2021
-
Abstract
- Copper-catalyzed C <subscript>sp</subscript> -S cross-coupling is known to form rare macrocyclic alkynyl sulfides. Computational studies now suggest a mechanism for the reaction pathway. Upon formation of Cu-S species, subsequent α-addition/elimination at the ethynylic carbon affords the desired macrocycle.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 86
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33729782
- Full Text :
- https://doi.org/10.1021/acs.joc.0c03068