Back to Search
Start Over
Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast.
- Source :
-
BMC cancer [BMC Cancer] 2021 Mar 16; Vol. 21 (1), pp. 286. Date of Electronic Publication: 2021 Mar 16. - Publication Year :
- 2021
-
Abstract
- Background: In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value using an immunohistochemical staining method.<br />Methods: We investigated 107 patients with TNBC for whom a full-face section stained by hematoxylin and eosin between 2006 and 2018 at Dokkyo Medical University Hospital was available.<br />Results: The strongest association of infiltrating CD20+ TILs was with CD4+ TILs. There was a significant relationship between CD20+ and CD4+ TILs (r = 0.177; p < 0.001), CD8+ TILs (r = 0.085; p = 0.002), and FOXP3+ TILs (r = 0.0043; p = 0.032). No significant relationships were observed between the CD20+ and CD25+ TILs (r = 0.012; p = 0.264). Multivariate analysis revealed that only the CD20+/FOXP3 ratio was an independent factor for relapse-free survival (p < 0.001) and overall survival (p < 0.001). Patients with tumors highly infiltrated by CD4+, CD8+, and CD20+ TILs had a good prognosis. In contrast, those with tumors weakly infiltrated by CD20+ TILs but highly infiltrated by CD25+ and FOXP3+ TILs had a poor prognosis.<br />Conclusions: CD20+ TILs may support an increase in CD4+ and CD8+ TILs, which altered the anti-tumor response, resulting in a positive prognosis. CD20+ TILs correlated with FOXP3+ Treg lymphocytes, which were reported to be correlated with a poor prognosis. Our study suggested that TIL-B cells have dual and conflicting roles in TIL-T immune reactions in TNBC.
- Subjects :
- B-Lymphocytes immunology
Breast cytology
Breast immunology
Breast pathology
Carcinoma immunology
Carcinoma mortality
Carcinoma pathology
Chemotherapy, Adjuvant methods
Disease-Free Survival
Female
Humans
Immunohistochemistry
Mastectomy
Middle Aged
Neoadjuvant Therapy methods
Neoplasm Recurrence, Local immunology
Neoplasm Recurrence, Local prevention & control
Prognosis
Risk Assessment methods
T-Lymphocyte Subsets immunology
Triple Negative Breast Neoplasms immunology
Triple Negative Breast Neoplasms mortality
Triple Negative Breast Neoplasms pathology
Carcinoma therapy
Lymphocytes, Tumor-Infiltrating immunology
Neoplasm Recurrence, Local epidemiology
Triple Negative Breast Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 33726701
- Full Text :
- https://doi.org/10.1186/s12885-021-08009-x