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Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations.
- Source :
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Investigational new drugs [Invest New Drugs] 2021 Oct; Vol. 39 (5), pp. 1366-1374. Date of Electronic Publication: 2021 Mar 15. - Publication Year :
- 2021
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Abstract
- TAS-117 is a potent and selective allosteric pan-v-akt murine thymoma viral oncogene homolog (Akt) inhibitor. We conducted a single-arm single-center phase 2 study of TAS-117 in heavily treated patients with tumors refractory to systemic chemotherapy and harboring phosphatidylinositol 3-kinase (PI3K)/Akt mutations. Patients with gastrointestinal (GI) cancers were orally administered 16 mg TAS-117 daily, and those with non-GI tumors were administered 24 mg on a 4 days on/3 days off schedule. The primary endpoint was overall response rate (ORR). Secondary endpoints included disease control rate (DCR), progression-free survival (PFS), overall survival (OS), PFS ratio, safety, and tolerability. Thirteen patients were enrolled: eight with non-GI (breast, ovarian, endometrial, and non-small cell lung) and five with GI (colon, rectal, gastric, and gallbladder) cancers. Ten patients were treated with TAS-117 after ≥ 4 lines of therapy. Twelve patients showed PIK3 catalytic subunit alpha (PIK3CA) mutations; one harbored an Akt1 <superscript>E17K</superscript> mutation. The median treatment duration was 1.4 months; the median number of treatment cycles was 2. The ORR was 8 %, and DCR was 23 %. The median PFS and OS were 1.4 and 4.8 months, respectively. Grade 3-4 treatment-related adverse events were anorexia (grade 3, 8 %) and hyperglycemia (grade 3, 8 %; grade 4, 8 %).Grade 3-4 treatment-related adverse events occurred in 27 % of grade 3 anorexia (9 %) and hyperglycemia (grade 3, 8 %; grade 4, 9\%). TAS-117 showed limited antitumor activity and manageable toxicity. Clinical efficacy was observed in patients with ovarian cancer harboring PIK3CA E545K mutations and in patients with breast cancer harboring PIK3CA H1047R and Akt1 <superscript>E17K</superscript> mutations.Trial registration: This study was retrospectively registered with ClinicalTrial.gov (NCT03017521 on January 11, 2017).<br /> (© 2021. The Author(s).)
- Subjects :
- Adult
Aged
Class I Phosphatidylinositol 3-Kinases genetics
Female
Gastrointestinal Neoplasms drug therapy
Gastrointestinal Neoplasms genetics
Gastrointestinal Neoplasms pathology
Heterocyclic Compounds, 3-Ring administration & dosage
Heterocyclic Compounds, 3-Ring adverse effects
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasms pathology
Progression-Free Survival
Heterocyclic Compounds, 3-Ring therapeutic use
Neoplasms drug therapy
Neoplasms genetics
Phosphatidylinositol 3-Kinases genetics
Proto-Oncogene Proteins c-akt antagonists & inhibitors
Proto-Oncogene Proteins c-akt genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0646
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Investigational new drugs
- Publication Type :
- Academic Journal
- Accession number :
- 33723724
- Full Text :
- https://doi.org/10.1007/s10637-021-01085-7