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Quantification of biomarker functionality predicts patient outcomes.
- Source :
-
British journal of cancer [Br J Cancer] 2021 May; Vol. 124 (10), pp. 1618-1620. Date of Electronic Publication: 2021 Mar 15. - Publication Year :
- 2021
-
Abstract
- Implementation of a quantitative molecular imaging method (iFRET), which determines receptor-ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
B7-H1 Antigen antagonists & inhibitors
B7-H1 Antigen physiology
Biomarkers, Tumor isolation & purification
Carcinoma, Non-Small-Cell Lung diagnosis
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung mortality
Humans
Immune Checkpoint Inhibitors therapeutic use
Immunohistochemistry methods
Lung Neoplasms diagnosis
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Lung Neoplasms mortality
Neoplasms drug therapy
Neoplasms genetics
Neoplasms mortality
Prognosis
Programmed Cell Death 1 Receptor antagonists & inhibitors
Programmed Cell Death 1 Receptor physiology
Survival Analysis
Treatment Outcome
Biomarkers, Tumor analysis
Molecular Imaging methods
Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1827
- Volume :
- 124
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 33723395
- Full Text :
- https://doi.org/10.1038/s41416-021-01291-3