Tropoelastin and Elastin Assembly.

Authors :: Ozsvar J
Yang C
Cain SA
Baldock C
Tarakanova A
Weiss AS
Source :: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Feb 25; Vol. 9, pp. 643110. Date of Electronic Publication: 2021 Feb 25 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues. Elastin makes up the majority of elastic fibers and is formed by the hierarchical assembly of its monomer, tropoelastin. Our understanding of key aspects of the assembly process have been unclear due to the intrinsic properties of elastin and tropoelastin that render them difficult to study. This review focuses on recent developments that have shaped our current knowledge of elastin assembly through understanding the relationship between tropoelastin's structure and function.<br />Competing Interests: AW is the Scientific Founder of Elastagen Pty. Ltd., which was sold to Allergan, now a division of AbbVie. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Ozsvar, Yang, Cain, Baldock, Tarakanova and Weiss.)