(PhSe) 2 and ( p Cl-PhSe) 2 organochalcogen compounds inhibit Candida albicans adhesion to human endocervical (HeLa) cells and show anti-biofilm activities.

Authors :: da Silva BM
Braga MT
da Silva Passos JC
Carvalho ML
Rosseti IB
de Amorim LMM
da Rocha JBT
Alberto-Silva C
Costa MS
Source :: Biofouling [Biofouling] 2021 Feb; Vol. 37 (2), pp. 235-245. Date of Electronic Publication: 2021 Mar 15.
Publication Year :: 2021
Abstract: Adhesion capacity on biological surfaces and biofilm formation is considered an important step in the infection process by Candida albicans. The ability of (PhSe) <subscript>2</subscript> and ( p Cl-PhSe) <subscript>2</subscript> , two synthetic organic selenium (organochalcogen) compounds, to act on C. albicans virulence factors related to adhesion to human endocervical (HeLa) cell surfaces and their anti-biofilm activities was analyzed. Both organochalcogen compounds inhibited C. albicans adhesion to HeLa cells, dependent on compound concentrations. (PhSe) <subscript>2</subscript> (at 20 µM; p = 0.0012) was significantly more effective than ( p Cl-PhSe) <subscript>2</subscript> (at 20 µM; p = 0.0183) compared with the control. (PhSe) <subscript>2</subscript> inhibited biofilm formation and decreased biofilm viability in both early and mature biofilms more efficiently than ( p Cl-PhSe) <subscript>2</subscript> . Overall, the organochalcogen compounds, especially (PhSe) <subscript>2</subscript> , were demonstrated to be effective antifungal drugs against C. albicans virulence factors related to epithelial cell surface adhesion and the formation and viability of biofilms.

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