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Photothermal therapy enhance the anti-mitochondrial metabolism effect of lonidamine to renal cell carcinoma in homologous-targeted nanosystem.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2021 Jun; Vol. 34, pp. 102370. Date of Electronic Publication: 2021 Mar 11. - Publication Year :
- 2021
-
Abstract
- Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system with poor prognosis. Therapeutic drugs for RCC can easily develop resistance or have unignorable toxicity or limited efficiency. Here, the thermosensitive mitochondrial metabolism-interfering anticancer drug lonidamine (LND) was combined with the photothermal material polydopamine (PDA) to treat RCC. To delivery drugs accurately to RCC site, LND and PDA were loaded in stellate mesoporous silica nanoparticles (MSNs) with a large surface area and cloaked with RCC membranes (MLP@M). The results showed that MLP@M exhibited excellent tumor targeting ability. The synergistic effects of LND and PDA in MLP@M were greatly enhanced when triggered by an 808 nm laser. Moreover, the antiproliferative and tumor suppressing abilities were enhanced with good biocompatibility after MLP@M + laser treatment. Additionally, 80% of RCC tumor-bearing mice treated with MLP@M + laser did not relapse. Our study provides a potential therapeutic approach for RCC treatment.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Carcinoma, Renal Cell metabolism
Humans
Indazoles pharmacology
Indoles pharmacology
Kidney Neoplasms metabolism
Mice
Mitochondria metabolism
Polymers pharmacology
Silicon Dioxide chemistry
Xenograft Model Antitumor Assays
Antineoplastic Agents therapeutic use
Carcinoma, Renal Cell drug therapy
Drug Delivery Systems
Indazoles therapeutic use
Indoles therapeutic use
Kidney Neoplasms drug therapy
Mitochondria drug effects
Nanoparticles chemistry
Photothermal Therapy
Polymers therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33713859
- Full Text :
- https://doi.org/10.1016/j.nano.2021.102370