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Heart valve calcification and cardiac hemodynamics.

Authors :
Rossi A
Barbieri A
Benfari G
Gaibazzi N
Erlicher A
Mureddu G
Frattini S
Faden G
Manicardi M
Beraldi M
Agostini F
Lazzarini V
Moreo A
Luigi Temporelli P
Magni G
Pressman G
Faggiano P
Source :
Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2021 Apr; Vol. 38 (4), pp. 525-530. Date of Electronic Publication: 2021 Mar 11.
Publication Year :
2021

Abstract

Purpose: Heart valve calcification (VC) is associated with increased cardiovascular risk, but the hemodynamic and functional profile of patients affected by VC has not been fully explored.<br />Methods: The study population was formed by consecutive unselected patients included in seven echocardiographic laboratories in a 2-week period. A comprehensive echocardiographic examination was performed. VC was defined by the presence of calcification on at least one valve.<br />Results: Population was formed of 1098 patients (mean age 65 ± 15 years; 47% female). VC was present in 31% of the overall population. Compared with subjects without VC, VC patients were older (60 ± 14 vs 75 ± 9; P < .0001), had more hypertension (40% vs 57%; P = .0005), diabetes (11% vs 18%; P = .002), coronary artery disease (22% vs 38%; P = .04), and chronic kidney disease (4% vs 8%; P = .007). Furthermore, VC patients had lower ejection fraction (55 ± 14 vs 53 ± 25; P < .0001), worse diastolic function (E/e' 8.5 ± 4.6 vs 13.0 ± 7.1; P < .0001) and higher pulmonary artery pressure (29 ± 9 vs 37 ± 12; P < .0001). The association between VC and EF was not independent of etiology (p for VC 0.13), whereas the association with E/e' and PASP was independent in a full multivariate model (P < .0001 and P = .0002, respectively).<br />Conclusion: Heart valve calcification patients were characterized by a worse functional and hemodynamic profile compared to patients with normal valve. The association between VC and diastolic function and PASP were independent in comprehensive multivariate models.<br /> (© 2021 Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1540-8175
Volume :
38
Issue :
4
Database :
MEDLINE
Journal :
Echocardiography (Mount Kisco, N.Y.)
Publication Type :
Academic Journal
Accession number :
33705585
Full Text :
https://doi.org/10.1111/echo.14994