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Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease.
- Source :
-
Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2021 Mar 10; Vol. 12 (3), pp. e00320. Date of Electronic Publication: 2021 Mar 10. - Publication Year :
- 2021
-
Abstract
- Introduction: Dipeptidyl peptidase-4 (DPP-4) is a membrane-bound glycoprotein that acts as a receptor but also exists in a soluble form. It has been recognized as a mediator of inflammation and considered a biomarker in inflammatory bowel disease (IBD).<br />Methods: We evaluated a prospectively recruited cohort, consisting of 101 patients with IBD, using validated clinical indexes; 22 patients with ulcerative colitis (UC) underwent endoscopic evaluation. Fecal DPP-4 (fDPP-4) levels were analyzed and correlated with clinical scores, Mayo endoscopic score (in UC patients), serum DPP-4, C-reactive protein, and fecal calprotectin. Immunohistochemical staining for DPP-4 in intestinal biopsies was also performed.<br />Results: When compared with remitters, median fDPP-4 levels were higher in patients with ileal Crohn's disease (CD) (7,584 [1,464-7,816] vs 2,104 [630-2,676] ng/mL, P = 0.015) and lower in patients with UC exhibiting clinical activity (1,213 [559-1,682] vs 7,814 [2,555-7,985] ng/mL, P < 0.001). Patients with UC presenting endoscopic activity also had lower levels than remitters (939 [559-1,420] vs 7,544 [4,531-7,940] ng/mL, P = 0.006). Fecal DPP-4 discriminated clinical activity from remission with areas under the curve of 0.76 (95% confidence interval [CI] 0.58-0.94, P = 0.015) and 0.80 (95% CI 0.68-0.93, P < 0.001) in CD and UC, respectively; it allowed to differentiate endoscopic activity in patients with UC, with areas under the curve of 0.84 (95% CI 0.63-1.00, P = 0.009). Immunohistochemical analysis revealed higher DPP-4 apical expression in UC remitters, but no statistically significant differences were revealed between patients with ileal CD.<br />Discussion: Our results suggest that fDPP-4 can be used as a biomarker of IBD activity, particularly in UC. The expression profiles in intestinal tissue might represent a functional compartmentalization of DPP-4 expression.<br /> (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
- Subjects :
- Adult
Biomarkers analysis
C-Reactive Protein analysis
C-Reactive Protein metabolism
Colitis, Ulcerative immunology
Colon diagnostic imaging
Colon immunology
Crohn Disease immunology
Dipeptidyl Peptidase 4 metabolism
Endoscopy, Gastrointestinal
Feces chemistry
Female
Humans
Ileum diagnostic imaging
Ileum immunology
Intestinal Mucosa diagnostic imaging
Intestinal Mucosa immunology
Leukocyte L1 Antigen Complex analysis
Leukocyte L1 Antigen Complex metabolism
Male
Middle Aged
Prospective Studies
Signal Transduction immunology
Young Adult
Colitis, Ulcerative diagnosis
Crohn Disease diagnosis
Dipeptidyl Peptidase 4 analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2155-384X
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and translational gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 33704099
- Full Text :
- https://doi.org/10.14309/ctg.0000000000000320