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Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 May 05; Vol. 41 (5), pp. 1638-1653. Date of Electronic Publication: 2021 Mar 11. - Publication Year :
- 2021
-
Abstract
- [Figure: see text].
- Subjects :
- Animals
Enzyme Activation
Female
GTP-Binding Protein alpha Subunits, G12-G13 genetics
GTP-Binding Protein alpha Subunits, G12-G13 metabolism
Integrin beta3 genetics
Male
Mice, Inbred C57BL
Mice, Knockout
NADPH Oxidase 2 genetics
NADPH Oxidases metabolism
Phosphatidylinositol 3-Kinase metabolism
Phosphorylation
Platelet Factor 4 genetics
Platelet Factor 4 metabolism
Platelet Glycoprotein GPIIb-IIIa Complex genetics
Proto-Oncogene Proteins c-akt metabolism
Stress, Mechanical
Syk Kinase metabolism
Mice
Blood Platelets enzymology
Hydrogen Peroxide metabolism
Integrin beta3 metabolism
Mechanotransduction, Cellular
NADPH Oxidase 2 metabolism
Platelet Activation
Platelet Glycoprotein GPIIb-IIIa Complex metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 41
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 33691478
- Full Text :
- https://doi.org/10.1161/ATVBAHA.120.315773