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Targeted Isolation of Saalfelduracin B-D from Amycolatopsis saalfeldensis Using LC-MS/MS-Based Molecular Networking.
- Source :
-
Journal of natural products [J Nat Prod] 2021 Apr 23; Vol. 84 (4), pp. 1002-1011. Date of Electronic Publication: 2021 Mar 08. - Publication Year :
- 2021
-
Abstract
- High-resolution tandem mass spectrometry (HR-MS <superscript>2</superscript> )-based metabolomic studies of Amycolatopsis saalfeldensis , isolated from the "Saalfelder Feengrotten" caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B-D ( 1 - 3 ) and the known saalfelduracin A ( 4 ). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.
- Subjects :
- Amycolatopsis chemistry
Anti-Infective Agents isolation & purification
Antibiosis
Biological Products isolation & purification
Biological Products pharmacology
Chromatography, High Pressure Liquid
Coculture Techniques
Germany
Metabolomics
Microbial Sensitivity Tests
Molecular Structure
Peptides isolation & purification
Tandem Mass Spectrometry
Anti-Infective Agents pharmacology
Caves microbiology
Peptides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 84
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 33683882
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.0c01027