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Altered cortico-striatal functional connectivity in people with high levels of schizotypy: A longitudinal resting-state study.
- Source :
-
Asian journal of psychiatry [Asian J Psychiatr] 2021 Apr; Vol. 58, pp. 102621. Date of Electronic Publication: 2021 Feb 28. - Publication Year :
- 2021
-
Abstract
- Purpose of the Research: Cortico-striatal functional connectivity has been implicated in the neuropathology of schizophrenia. However, the longitudinal relationship between the cortico-striatal connectivity and schizotypy remains unknown. We examined the resting-state fMRI connectivity in 27 individuals with a high level of schizotypy and 20 individuals with a low level of schizotypy at baseline and 18 months later. Correlations between changes in cortico-striatal connectivity and changes in schizotypy scores over time were examined.<br />Principal Results: We found both increased and decreased cortico-striatal connectivity in individuals with a high level of schizotypy at baseline. Over time, these individuals showed improvement in both the negative and positive schizotypal domains. Changes in striatal-insula connectivity were positively correlated with changes in positive schizotypy from baseline to follow-up.<br />Major Conclusions: Our results suggested impaired cortico-striatal connectivity in individuals with a high level of schizotypy. The dysconnectivity mainly involves the dorsal striatum. The connectivity between the dorsal striatum and the insula may be a putative marker for temporal changes in positive schizotypy.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1876-2026
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- Asian journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 33676189
- Full Text :
- https://doi.org/10.1016/j.ajp.2021.102621