Primary Cutaneous Acral CD8 + T-cell Lymphoma Induced by Persistent Delayed Hypersensitivity to Gold Earrings.

Authors :: Molinero Caturla J
Sánchez Sánchez J
Marcoval Caus J
Muniesa Montserrat C
Climent Esteller J
Servitje Bedate O
Source :: Actas dermo-sifiliograficas [Actas Dermosifiliogr (Engl Ed)] 2021 Mar 03. Date of Electronic Publication: 2021 Mar 03.
Publication Year :: 2021
Publisher :: Ahead of Print
Abstract: Primary cutaneous CD8 <superscript>+</superscript> T-cell lymphoma has been included as a provisional entity within the new revised classification of lymphoid neoplasms of the World Health Organization in 2016 <superscript>1</superscript> . It was initially described as indolent CD8 <superscript>+</superscript> lymphoid proliferation of the ear <superscript>2</superscript> and a total of 29 cases of such neoplasm have been published in the literature so far. None of them have been linked to delayed contact hypersensitivity reactions. We present a case of acral type primary cutaneous lymphoma T CD8 <superscript>+</superscript> involving both earlobes clearly related with the prolonged use of gold earrings, confirmed with epicutaneous tests, histopathology, immunohistochemical and molecular studies. Auricular skin lesions were induced again with a provocation test with identical histopathologycal and the same clonality, confirming both the diagnosis of lymphoma and its induction by the antigenic stimulus of gold.<br /> (Copyright © 2021 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

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