Back to Search
Start Over
Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution.
- Source :
-
Science advances [Sci Adv] 2021 Mar 05; Vol. 7 (10). Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Limited knowledge exists on immune markers associated with disease severity or recovery in patients with coronavirus disease 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire in patients with acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, antibody binding, and affinity maturation in "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide and receptor binding domain (RBD) in patients with mild COVID-19 who recovered early compared with "fatal" COVID-19 patients. In patients with severe COVID-19, high-titer IgA were observed, primarily against RBD, especially in patients who succumbed to SARS-CoV-2 infection. The patients with mild COVID-19 showed marked increase in antibody affinity maturation to prefusion SARS-CoV-2 spike that associated with faster recovery from COVID-19. This study revealed antibody markers associated with disease severity and resolution of clinical disease that could inform development and evaluation of effective immune-based countermeasures against COVID-19.<br /> (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
- Subjects :
- Antibody Affinity immunology
Antibody Formation immunology
COVID-19 blood
COVID-19 virology
Cytokines blood
HEK293 Cells
Hospitalization
Humans
Immunoglobulin Class Switching
Kinetics
Neutralization Tests
Protein Binding
Protein Domains
Spike Glycoprotein, Coronavirus chemistry
Spike Glycoprotein, Coronavirus immunology
Viral Load
Antibodies, Viral blood
Antibodies, Viral immunology
Antigens, Viral immunology
Biomarkers blood
COVID-19 immunology
COVID-19 pathology
SARS-CoV-2 physiology
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 2375-2548
- Volume :
- 7
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Science advances
- Publication Type :
- Academic Journal
- Accession number :
- 33674317
- Full Text :
- https://doi.org/10.1126/sciadv.abf2467