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Effect of Hydrolysable Tannins and Anthocyanins on Recurrent Urinary Tract Infections in Nephropathic Patients: Preliminary Data.
- Source :
-
Nutrients [Nutrients] 2021 Feb 11; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 11. - Publication Year :
- 2021
-
Abstract
- Urinary tract infections (UTIs) are caused by uropathogenic microorganism colonization. UTIs often require an antibiotic therapy that can cause the selection of antibiotic-resistant bacterial strains. A natural bioactive compound may represent a valid therapeutic adjuvant approach, in combination with drug therapy. In this paper, we present a pilot study, based on the administration of an oral food supplement (OFS), containing chestnut tannins and anthocyanins, to nephropathic patients suffering from recurrent UTIs (16 treated patients with 1 cp/day and 10 untreated patients). We performed laboratory tests and quality of life and body composition assessments, at T0 (baseline) and T1 (after 6 weeks OFS assumption). The analysis of OFS was performed by HPLC-DAD-MS for its content in polyphenols and by in vitro tests for its antioxidative and anti-free radical activities. In each capsule, polyphenol content was 6.21 mg (4.57 mg hydrolysable tannins, 0.94 mg anthocyanosides, 0.51 mg proanthocyanidins, 0.18 mg quercetin derivatives). A significant reduction of erythrocyte sedimentation rate was observed only in male patients. Urinalysis showed a significant reduction of leukocytes in both genders, whereas urinary bacterial flora at T1 significantly decreased only in male subjects. Tannins seem to exert an antimicrobial action according to gender, useful to counteract the recurrence of UTIs.
- Subjects :
- Aesculus chemistry
Aged
Anti-Infective Agents administration & dosage
Body Composition
Dietary Supplements
Female
Humans
Male
Middle Aged
Phytotherapy
Pilot Projects
Preliminary Data
Quality of Life
Recurrence
Sex Factors
Urinary Tract Infections microbiology
Vaccinium macrocarpon chemistry
Anthocyanins administration & dosage
Hydrolyzable Tannins administration & dosage
Renal Insufficiency, Chronic complications
Urinary Tract Infections prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 33670236
- Full Text :
- https://doi.org/10.3390/nu13020591