Biodistribution of bis-[beta-(N,N,N-trimethylamino)ethyl]selenide-75Se diiodide, a potential articular cartilage imaging agent.

Authors :: Yu WK
Bartlett JM
van Sickle DC
Mock BH
Source :: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology [Int J Rad Appl Instrum B] 1988; Vol. 15 (2), pp. 229-30.
Publication Year :: 1988
Abstract: In an effort to develop a specific radiodiagnostic agent for articular cartilage imaging, we have investigated the biodistribution of bis[beta-(N,N,N-trimethylamino)ethyl]-selenide-75Se diiodide (75Se BISTAES) in rabbits. At an intravenous dose of 5 mg/kg, the greatest localization of the compound occurred in articular cartilage 15 min after injection. The compound was excreted rapidly in the urine. The results suggest that 75Se BISTAES has potential clinical use as an articular cartilage imaging agent.

Subjects :: Animals
Rabbits
Radionuclide Imaging
Tissue Distribution
Cartilage, Articular diagnostic imaging
Selenium Radioisotopes pharmacokinetics

Language :: English
ISSN :: 0883-2897
Volume :: 15
Issue :: 2
Database :: MEDLINE
Journal :: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Publication Type :: Academic Journal
Accession number :: 3366624
Full Text :: https://doi.org/10.1016/0883-2897(88)90093-1

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