Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.

A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt-induced hypertension in the Göttingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF.
Competing Interests: Dr. Kelly is supported in part by the National Institutes of Health (R01 HL128349 and R01 HL151345). Dr. Matsuura is supported by the National Institute of Health (T32HL007843). Dr. Lefer was supported in part by the National Institutes of Health (1R01 HL146098, 1R56HL137711, 1R01 HL146514, and 1R01 HL151398). Drs. Sharp, Goodchild, and Lefer have a pending patent on the composition and methods for modeling HFpEF in Göttingen minipigs. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2021 The Authors.)