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COVID-19-associated coagulopathy: a concise review on pathogenesis and clinical implications.
- Source :
-
Le infezioni in medicina [Infez Med] 2021 Mar 01; Vol. 29 (1), pp. 1-9. - Publication Year :
- 2021
-
Abstract
- In this review, we summarize the possible mechanisms of COVID-19-associated coagulopathy and compare its features to other similar conditions. The recent COVID-19 pandemic has caused enormous mortality and morbidity worldwide. It is important to note that COVID-19-associated thrombotic events play a huge role in the morbidity of this disease. Interestingly, it has been observed that this complication may occur despite prophylactic anticoagulant therapy. Recent studies on COVID-19-associated coagulopathy revealed that the COVID-19-associated hypercoagulability is more frequently observed among those with a severe course of the disease. Various mechanisms have been suggested as explanations for this condition and possible underlying etiologies.
- Subjects :
- Angiotensin-Converting Enzyme 2 metabolism
Anticoagulants administration & dosage
Anticoagulants adverse effects
Blood Coagulation Disorders metabolism
COVID-19 blood
Endothelium, Vascular metabolism
Fibrin Fibrinogen Degradation Products metabolism
Hemostasis
Heparin adverse effects
Humans
Interleukin-10 blood
Interleukin-6 blood
Receptors, Interleukin-2 blood
Thrombophilia etiology
Thrombosis etiology
Tumor Necrosis Factor-alpha blood
Virus Internalization
Blood Coagulation Disorders etiology
COVID-19 complications
SARS-CoV-2 pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 2532-8689
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Le infezioni in medicina
- Publication Type :
- Academic Journal
- Accession number :
- 33664168